Orthopaedics addresses the treatment of musculoskeletal disorders, injuries, and diseases. Orthopaedic diseases have significant impact on public health worldwide. They are the second largest cause of disability and user of resource of health care in the world. The significant factor is the rising number of surgeries caused by the ageing population and overall improvement in treatment coverage.

The total value of the orthopedics market is forecasted to grow moderately in 2021, reaching USD 54.5 billion in 2021 (2020: 47,5)1). The global bone graft market was estimated to be worth around USD 2.7 billion in 2020, with the growth forecast of 5.5% annually between 2021–2028).

Approximately 1/3 of all relevant operations are made with autograft. Therefore, the potential bone graft substitute market can, based on BBS’s estimates, grow by 50 % to up to 4 billion USD. When a product, that is in every way a good substitute for the autograft comes on the market, orthopedic surgeons are known to be happy to switch from autograft to substitute, which is one of the forces driving the market forward.