Publications · ARTEBONE®

Numerous academic publications are backing the product development.

Published articles and doctoral thesis

Gao TJ, Lindholm TS, Kommonen B, Ragni P, Paronzini A, Lindholm TC, Jämsä T & Jalovaara P (1996) Enhanced healing of segmental tibial defects in sheep by a composite bone substitute composed of tricalcium phosphate cylinder, bone morphogenetic protein, and type IV collagen. J Biomed Mater Res 32(4): 505–512.

Gao TJ (1996) Bioactive delivery system for extracted bone morphogenetic proteins. Doctoral Thesis, University of Tampere, Finland.

Gao TJ, Lindholm TS, Kommonen B, Ragni P, Paronzini A, Lindholm TC, Jalovaara P & Urist MR (1997) The use of a coral composite implant containing bone morphogenetic protein to repair a segmental tibial defect in sheep. Int Orthop 21: 194–200.

Gao TJ, Tuominen TK, Lindholm TS, Kommonen B & Lindholm TC (1997) Morphological and biomechanical difference in healing in segmental tibial defects implanted with Biocoral or tricalcium phosphate cylinders. Biomaterials 18(3):219-23.

Jortikka L, Marttinen A & Lindholm TS (1993) Partially purified reindeer (Rangifer Tarandus) bone morphogenetic protein has a high bone-forming activity compared with some other artiodactylis. Clin Orthop Relat Res 297: 33-7.

Kapanen A, Ryhänen J, Birr E, Väänänen HK & Tuukkanen J (2002) Bone morphogenetic protein 3b expressing reindeer antler. J Biomed Mater Res 59(1): 78–83.

Kujala S, Raatikainen T, Ryhänen J, Kaarela O & Jalovaara P (2002) Composite implant of native bovine bone morphogenetic protein (BMP) and biocoral in the treatment of scaphoid nonunions – a preliminary study. Scand J Surg 91(2): 186-90.

Kujala S, Raatikainen T, Ryhänen J, Kaarela O & Jalovaara P (2004) Composite implant of native bovine bone morphogenetic protein (BMP), collagen carrier and biocoral in the treatment of resistant ulnar nonunions: report of five preliminary cases. Arch Orthop Trauma Surg 124: 26–30.

Kujala S, Vähäsarja V, Serlo W & Jalovaara P (2008) Treatment of congenital pseudarthrosis of the tibia with native bovine BMP: a case report. Acta Orthop Belg 74(1): 132–136.

Pekkarinen T, Lindholm TS, Hietala O & Jalovaara P (2003) New bone formation induced by injection of native reindeer BMP. Scand J Surg 92: 227-30.

Pekkarinen T, Lindholm TS, Hietala O & Jalovaara P (2004) Influence of ethylene oxide sterilization on the activity of native reindeer bone morphogenetic protein. Int Orthop 28(2): 97-101.

Pekkarinen T, Lindholm TS, Hietala O & Jalovaara P (2005) The effect of different mineral frames on the ectopic bone formation in mouse hind leg muscles induced by native reindeer bone morphogenetic protein. Arch Orthop Trauma Surg 125(1): 10-5, doi:10.1007/s00402-004-0761-7.

Pekkarinen T, Hietala O, Jämsä T & Jalovaara P (2005) Effect of gamma irradiation on the osteoinductivity of native reindeer bone morphogenetic protein extract. Acta Orthop 76(2): 231-6.

Pekkarinen T, Hietala O, Jämsä T & Jalovaara P (2005) Gamma irradiation and ethylene oxide in the sterilization of native reindeer bone morphogenetic protein extract. Scand J Surg 94(1): 67-70.

Pekkarinen T (2005) Effect of sterilization and delivery systems on the osteoinductivity of reindeer bone morphogenetic protein extract. Doctoral Thesis, University of Oulu, Finland. Website: http://jultika.oulu.fi/Record/isbn951-42-7673-6

Pekkarinen T, Jämsä T, Määttä M, Hietala O & Jalovaara P (2006) Reindeer BMP extract in the healing of critical-size bone defects in the radius of the rabbit. Acta Orthop 77(6): 952-9, doi: 10.1080/17453670610013286.

Tuominen T, Jämsä T, Tuukkanen J, Nieminen P, Lindholm TC, Lindholm TS & Jalovaara P (2000) Native bovine bone morphogenetic protein improves the potential of biocoral to heal segmental canine ulnar defects. Int Orthop 24: 289–294.

Tuominen T, Jämsä T, Oksanen J, Tuukkanen J, Gao TJ, Lindholm TS & Jalovaara P (2001) Composite implant composed of hydroxyapatite and bone morphogenetic protein in the healing of a canine ulnar defect. Ann Chir Gynaecol Suppl 90(1): 32–36.

Tuominen T (2001) Native bovine bone morphogenetic protein in the healing of segmental long bone defects. Doctoral Thesis, University of Oulu, Finland. Website: http://urn.fi/urn:isbn:9514264789

Tuominen T, Raatikainen T, Leppilahti J & Jalovaara P (2001) Native Bovine BMP in the treatment of ulnar pseudoarthrosis a case report. Osteosynthese International 9: 173–175.

Tölli H, Kujala S, Levonen K, Jämsä T & Jalovaara P (2010) Bioglass as a carrier for reindeer bone protein extract in the healing of rat femur defect. J Mater Sci: Mater Med 21(5): 1677-84, doi: 10.1007/s10856-010-4017-5.

Tölli H, Kujala S, Jämsä T & Jalovaara P (2011) Reindeer bone extract can heal the critical-size rat femur defect. Int Orthop 35(4): 615-22, doi: 10.1007/s00264-010-1034-4.

Tölli H, Birr E, Sandström K, Jämsä T & Jalovaara P (2011) Calcium sulfate with stearic acid as an encouraging carrier for the reindeer bone protein extract. Materials 4(7): 1321-1332, doi: 10.3390/ma4071321.

Tölli H (2011) Reindeer-derived bone protein extract in the healing of bone defects: Evaluation of various carrier materials and delivery systems. Doctoral Thesis, University of Oulu, Finland. Website: http://jultika.oulu.fi/Record/isbn978-951-42-9661-1

Ulmanen MS, Pekkarinen T, Hietala OA, Birr EA & Jalovaara P (2005) Osteoinductivity of partially purified native ostrich (Struthio camelus) bone morphogenetic protein: Comparison with mammalian species. Life Sci 77(19): 2425-37, doi:10.1016/j.lfs.2005.01.040.

Viljanen VV, Gao TJ, Marttinen A & Lindholm TS (1996) Partial purification and characterization of bone morphogenetic protein from bone matrix of the premature moose (Alces alces): degradation of bone-inducing activity during storage. Eur Surg Res 28(6): 447–460.

Viljanen VV, Lindholm TC, Gao TJ & Lindholm TS (1997) Low dosage of native allogeneic bone morphogenetic protein in repair of sheep calvarial defects. Int J Oral Maxillofac Surg 26(5): 389-93.